7:30-8:15 Registration
8:15 Welcome
8:30 – 10:15
- Complexity
Moderator: Marko Gosak
8:35 – 8:55 Matjaž Perc, Maribor
Networks at different scales: From societies to islets
9:00 – 9:20 Vira Kravets, Denver
Computational and experimental assessment of the functional beta cell subpopulations in islets of Langerhans
9:25 – 9:45 Guy Rutter, London
Genetic drivers of pancreatic beta cell function and connectivity
9:50 – 10:10 Patrick MacDonald, Edmonton
Linking human islet cell functional and molecular phenotypes
10:15 – 10:30 Coffee break
10:30-12:05
- Model
Moderator: Patrik Rorsman
10:35 – 10:55 Marko Gosak, Maribor
Biophysical modelling as a means to explore the principles of complex spatio-temporal responses of beta cells to glucose
11:00 – 11:20 Morten Gram Pedersen, Padua
Modeling biphasic insulin secretion: Disentangling the roles of calcium patterns, granule dynamics and cellular heterogeneity
11:25 – 11:45 Andrea Mari, Padua
Mathematical modeling to bridge in vivo and in vitro beta cell research and highlight critical factors
11:50 – 12:00 Eleonora Grespan, Padua
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes
12:05-13:10 Lunch
13:10-15:15
- Function
Moderator: Patrick MacDonald
13:15 – 13:35 Jantje M. Gerdes, Munich
Primary cilia in β-cell function and islet vascularization
13:40 – 14:00 Yu Hsuan Carol Yang, Bad Nauheim
In vivo assessment of endocrine pancreas function following perturbed autonomic innervation
14:05 – 14:25 Patrik Rorsman, Oxford
The pancreatic alpha-cell: control of glucagon secretion
14:30 – 14:50 Christine Doucette, Winnipeg
Circadian Regulation of Insulin Secretion
14:55 – 15:30 Coffee break
15:30-17:05
- Regeneration
Moderator: Stephan Speier
15:35 – 15:55 Benoit Gauthier, Sevilla
Time for a Paradigm shift in treating Type 1 Diabetes: Coupling immunity to trans-regeneration
16:00 – 16:20 Kacey Prentice, Harvard
Targeting circulating FABP4 prevents type 1 diabetes by promoting β cell function and survival
16:25 – 16:45 James Johnson, Vancouver
Dynamic states of high insulin production
16:50 – 17:05 Melita Vidaković, Belgrade
Transdifferentiation of pancreatic alpha to insulin-producing cells via Epi-CRISPRs directed DNA methylation
17:05-20:00 Organized Tour
20:00- Dinner and Discussion
Friday, September 6
8:00 – 9:50
- Calcium
Moderator: Guy Rutter
8:05 – 8:25 Peter Thorn, Sydney
Beta cell function within the islets of Langerhans
8:30 – 8:50 David Hodson, Birmingham
Understanding beta cell heterogeneity from the single molecule to the organism
8:55 – 9:15 Erik Renström, Malmö
Central role of voltage-gated Calcium Channel Subunit γ4 in maintaining normal β-cell Function
9:20 – 9:30 Eva Paradiž, Maribor
Effects of GLP-1 receptor agonists and antagonists on beta cell Ca2+ dynamics in mouse pancreas tissue slices
9:35 – 9:45 Jan Zmazek, Maribor
Exploring the relationship between different oscillatory components in Ca2+ dynamics of pancreatic beta cells
9:50 – 10:05 Coffee break
10:05 – 12:15
- Disease
Moderator: Eckhart Lammert
10:10 – 10:30 Stephan Speier, Dresden
Early beta cell dysfunction without mass reduction in type 2 diabetes pathogenesis
10:35 – 10:55 Ya-Chi Huang, Toronto
The islet beta cells from human donors with pancreatic ductal adenocarcinoma (PDAC) are different from normal beta cells
11:00 – 11:20 Julia Brunner, Vienna
TREM2 preserves metabolic health in obesity by restraining white adipose expansion
11:25 – 11:45 Andrea Vogel, Vienna
Myeloid PTEN Promotes Obesity-Induced Insulin Resistance
11:50 – 12:10 Gašper Tkačik, Klosterneuburg
Information processing in biological networks
12:15 – 12:45 Quick lunch and coffee
12:45 – 14:20
- Targets
Moderator: James Johnson
12:50 – 13:10 Eckhard Lammert, Düsseldorf
Novel morphinan derivatives for diabetes treatment
13:15 – 13:35 Bryndis Birnir, Upsala
GABA signaling in human pancreatic islets
13:40 – 14:00 Shi-Bing Yang, Taiwan
Facilitating surface expression of PHHI-causing KATP channel mutant by a chemical chaperone
14:05 – 14:15 Sandra Postić
pH-dependent activity of pancreatic beta cells in acute tissue slices
14:20 Concluding remarks
15:00 Lunch and discussion