Program

Thursday, September 5

 7:30-8:15 Registration

 8:15 Welcome

 8:30 – 10:15

  1. Complexity

Moderator: Marko Gosak

8:35 – 8:55 Matjaž Perc, Maribor

Networks at different scales: From societies to islets

9:00 – 9:20 Vira Kravets, Denver

Computational and experimental assessment of the functional beta cell subpopulations in islets of Langerhans

 9:25 – 9:45 Guy Rutter, London

Genetic drivers of pancreatic beta cell function and connectivity

 9:50 – 10:10 Patrick MacDonald, Edmonton

Linking human islet cell functional and molecular phenotypes

10:15 – 10:30 Coffee break

10:30-12:05

  1. Model

Moderator: Patrik Rorsman

10:35 – 10:55 Marko Gosak, Maribor

Biophysical modelling as a means to explore the principles of complex spatio-temporal responses of beta cells to glucose

11:00 – 11:20 Morten Gram Pedersen, Padua

Modeling biphasic insulin secretion: Disentangling the roles of calcium patterns, granule dynamics and cellular heterogeneity

11:25 – 11:45 Andrea Mari, Padua

Mathematical modeling to bridge in vivo and in vitro beta cell research and highlight critical factors

11:50 – 12:00 Eleonora Grespan, Padua

Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes

 

12:05-13:10 Lunch

 

 13:10-15:15

  1. Function

Moderator: Patrick MacDonald

 13:15 – 13:35 Jantje M. Gerdes, Munich

Primary cilia in β-cell function and islet vascularization

 13:40 – 14:00 Yu Hsuan Carol Yang, Bad Nauheim

In vivo assessment of endocrine pancreas function following perturbed autonomic innervation

 14:05 – 14:25 Patrik Rorsman, Oxford

The pancreatic alpha-cell: control of glucagon secretion

 14:30 – 14:50 Christine Doucette, Winnipeg

Circadian Regulation of Insulin Secretion

 

14:55 – 15:30 Coffee break

 

15:30-17:05

  1. Regeneration

Moderator: Stephan Speier

 15:35 – 15:55 Benoit Gauthier, Sevilla

Time for a Paradigm shift in treating Type 1 Diabetes: Coupling immunity to trans-regeneration

 16:00 – 16:20 Kacey Prentice, Harvard
Targeting circulating FABP4 prevents type 1 diabetes by promoting β cell function and survival

 16:25 – 16:45 James Johnson, Vancouver

Dynamic states of high insulin production

 16:50 – 17:05 Melita Vidaković, Belgrade

Transdifferentiation of pancreatic alpha to insulin-producing cells via Epi-CRISPRs directed DNA methylation

 

17:05-20:00 Organized Tour

 

20:00- Dinner and Discussion

Friday, September 6

 

8:00 – 9:50

  1. Calcium

Moderator: Guy Rutter

 8:05 – 8:25 Peter Thorn, Sydney

Beta cell function within the islets of Langerhans

 8:30 – 8:50 David Hodson, Birmingham

Understanding beta cell heterogeneity from the single molecule to the organism

 8:55 – 9:15 Erik Renström, Malmö

Central role of voltage-gated Calcium Channel Subunit γ4 in maintaining normal β-cell Function

 9:20 – 9:30 Eva Paradiž, Maribor

Effects of GLP-1 receptor agonists and antagonists on beta cell Ca2+ dynamics in mouse pancreas tissue slices

 9:35 – 9:45 Jan Zmazek, Maribor

Exploring the relationship between different oscillatory components in Ca2+ dynamics of pancreatic beta cells

 

9:50 – 10:05 Coffee break

10:05 – 12:15

  1. Disease

Moderator: Eckhart Lammert

 10:10 – 10:30 Stephan Speier, Dresden

Early beta cell dysfunction without mass reduction in type 2 diabetes pathogenesis

 10:35 – 10:55 Ya-Chi Huang, Toronto

The islet beta cells from human donors with pancreatic ductal adenocarcinoma (PDAC) are different from normal beta cells

 11:00 – 11:20 Julia Brunner, Vienna

TREM2 preserves metabolic health in obesity by restraining white adipose expansion

11:25 – 11:45 Andrea Vogel, Vienna

Myeloid PTEN Promotes Obesity-Induced Insulin Resistance

11:50 – 12:10 Gašper Tkačik, Klosterneuburg

Information processing in biological networks

 12:15 – 12:45 Quick lunch and coffee

 

12:45 – 14:20

  1. Targets

Moderator: James Johnson

 12:50 – 13:10 Eckhard Lammert, Düsseldorf

Novel morphinan derivatives for diabetes treatment

 13:15 – 13:35 Bryndis Birnir, Upsala

GABA signaling in human pancreatic islets

 13:40 – 14:00 Shi-Bing Yang, Taiwan

Facilitating surface expression of PHHI-causing KATP channel mutant by a chemical chaperone

 14:05 – 14:15 Sandra Postić

pH-dependent activity of pancreatic beta cells in acute tissue slices

 

 14:20 Concluding remarks

 

15:00 Lunch and discussion